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Yousong Ding

Yousong Ding

Assistant Professor, Medicinal Chemistry, University of Florida

Phone: (352) 273-7742

Medical Science Building, P6-27



Ph.D. in Medicinal Chemistry, University of Michigan, Ann Arbor, MI

Research Interests:

The overall goal of the Ding laboratory is to generate structurally complex bioactive secondary metabolites and their analogues for drug development through deciphering and employing their biosynthetic mechanisms. One multiple-stage strategy involves genome-based identification and analysis of natural product biosynthetic systems, heterologous production, and bio-combinatorial synthesis. Subsequently, principles of medicinal chemistry, protein engineering, synthetic biology, and systems biology will be married to diversify chemical structures of natural products and existing drugs and to produce these chemicals through creating new biocatalysts and designing novel production routes.

Publications List:

  1. Ding Y, Zhang L, Schachtschabel D, Arnold FH. Engineered bacterial CYP102A1 (P450BM3) variants metabolize heterocyclic herbicides. To be submitted
  2. Ding Y, Rath CM, Bolduc KL, Ha?kansson K, Sherman DH. Chemoenzymatic synthesis of cryptophycin anticancer agents by an ester bond-forming non-ribosomal peptide synthetase module.J. Am. Chem. Soc. 2011, 133:14492-14495.
  3. Ding Y, Wet JR, Cavalcoli J, Li S, Greshock TJ, Miller KA, Finefield JM, Sunderhaus JD, McAfoos TJ, Tsukamoto S, Williams RM, Sherman DH Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine Aspergillus sp. J. Am. Chem. Soc. 2010, 132: 12733-12740.
  4. Ding Y, Miller KA, Greshock TJ, Sherman DH, Williams RM. Pre-malbrancheamide: synthesis, isotopic labeling, biosynthetic incorporation, and detection in cultures of Malbranchea aurantiaca. Org. Lett. 2008, 10: 4863-4866
  5. Ding Y, Gruschow S, Greshock TJ, Finefield J, Sherman DH, Williams RW. Detection of VM55599 and Pre-paraherquamide from Aspergillus japonicus and Penicillium fellutanum: Biosynthetic Implications. J. Nat. Prod. 2008, 71: 1574-1578
  6. Ding Y, Williams RM, Sherman DH. Isolation and characterization of a 4-dimethylallyltryptophan synthase from Malbranchea aurantiaca. J. Biol. Chem. 2008, 283: 16068-16076
  7. Ding Y, Seufert WH, Beck ZQ, Sherman DH. Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity. J. Am. Chem. Soc. 2008, 130: 5492-5498
  8. Magarvey NA, Beck ZQ, Golakoti T, Ding Y, Huber U, Hemscheidt TK, Abelson D, Moore RE, Sherman DH. Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts. ACS Chem. Biol. 2006, 1:766-779.
  9. Ding K, Lu Y, Nikolovska-Coleska Z, Qiu S, Ding Y, Gao W, Stuckey J, Krajewski K, Roller PP, Tomita Y, Parrish DA, Deschamps JR, Wang S. Structure-based design of potent non-peptide MDM2 inhibitors. J. Am. Chem. Soc. 2005, 127: 10130-10131.
  10. Ding Y, Bojja RS, Du L. Fum3p is a 2-ketoglutarate dependent dioxygenase required for C-5 hydroxylation of fumonisins in Fusarium verticillioides. Appl. Environ. Microbiol. 2004, 70: 1931-1934.